Abstract:[Objective] To evaluated the surgical efficacy of minimally invasive expansive decompression combined with anteroposteri-or pedicle screw fixation for type A3 thoracolumbar fractures with neurological deficits. [Methods] A retrospective analysis was conductedon 16 patients who received abovementioned surgical treatment for thoracolumbar fractures with nerve injuries between August 2022 andAugust 2023. The clinical and imaging documents were evaluated. [Results] All patients underwent the surgery successfully without any se-vere complications, and followed up for (9.4±3.9) months in mean. Compared to those preoperatively, the VAS score [(7.4±0.6), (1.8±0.6),(0.7±0.7), P<0.001] and ODI score [(81.8±8.7), (16.5±4.6), (9.4±4.1), P<0.001] significantly decreased, while JOA scores significantly in-creased [(6.6±1.5), (22.5±1.5), (26.8±1.3), P<0.001] 3 months postoperatively and at the final follow-up. In term of neurological function, 9patients recovered to ASIA grade E 1 week postoperatively, additionally, all the 16 patients returned to ASIA grade E at the latest followup.Regarding to imaging, the anterior vertebral height ratio (AVHR) increased significantly [(61.4±12.9)%, (94.3±3.6)%, (92.1±4.0)%, P<0.001], while local kyphotic angle (LKA) decreased significantly [(9.2±5.4)°, (0.9±1.5)°, (1.0±1.5)°, P<0.001] with time preoperatively, 3months postoperatively and latest follow-up. [Conclusion] The minimally invasive expansive decompression combined with pure anteropos-terior percutaneous pedicle screw fixation is effective in correcting deformity and improving neurological function for type A3 thoracolum-bar fractures with nerve injuries.