Abstract:[Objective] To compare three postoperative drainage methods for total hip arthroplasty (THA). [Methods] From January2018 to March 2022, 150 patients who were undergoing primary unilateral THA were divided into three groups according to random num-ber table method, 50 patients had negative pressure drainage, 50 patients underwent normal pressure drainage, and 50 patients receivedpositive pressure drainage. The early clinical and blood test documents of the three groups were compared. [Results] All patients in the 3groups had THA performed successfully, with no significant differences in operation time, total incision length and intraoperative blood lossamong the three groups (P>0.05). The postoperative total drainage volume [(335.9±38.1) ml vs (269.7±39.6) ml vs (187.0±34.8) ml, P<0.001], total blood loss [(801.7±57.2) ml vs (720.9±58.6) ml vs (618.1±53.4) ml, P<0.001] and latent blood loss [(284.1±40.9) ml vs (263.7±37.8) ml vs (246.6±36.0) ml, P<0.001] were all ranked up-down as the negative pressure group > the normal pressure group > the positivepressure group. There were no significant differences in incision pain VAS score and hip circumference among the three groups at any corre-sponding time points (P>0.05). In terms of blood test, Hb, Hct and RBC levels were significantly decreased in all the three groups 2 days af-ter surgery compared with those before surgery (P<0.05). Two days postoperatively the Hb [(90.6±10.3) g/L vs (94.3±9.2) g/L vs (98.1±8.9 g/L, P<0.001], Hct [(27.0±0.0)% vs (30.0±0.0)% vs (33.8±0.1)%, P<0.001], RBC [(3.3±0.3)×1012/L vs (3.5±0.3)×1012/L vs (3.7 ±0.3)×1012/L,P<0.001] were all ranked down-up as the negative pressure group < the normal pressure group < the positive pressure group. However,there were no significant differences in postoperative blood transfusion rate and incision healing grade among the three groups (P>0.05).[Conclusion] The combination of early clamping for 4 hours and positive pressure drainage after THA can effectively reduce the postopera-tive blood loss without increasing the incision pain and hip swelling, which is a simple and effective drainage method for clinical selection.