假体周围感染生物膜清除的研究进展△（开放获取）

(Open Access) Research progress of biofilm clearance in prosthetic joint infection

摘要:

人工关节置换术在临床上应用广泛，假体周围感染（prostheticjointinfection,PJI）是其灾难性并发症。生物膜是细菌在生物医学材料表面形成的特殊膜样结构，它保护细菌免受抗生素和免疫系统的影响，使根除变得困难。其引起的致病菌耐药是术后PJI迁延不愈的原因之一，也是PJI治疗的焦点。目前PJI总的治疗效果不理想，仍然存在着较高的失败率，与这种高失败率相关的原因是缺乏一种安全、有效、易实施的方法来清除细菌生物膜。因此，本文将从物理清除、化学清除、生物清除三方面对生物膜的清除策略进行综述，以期为PJI的临床治疗提供思路。

Abstract:

Artificial joint replacement is widely used in clinical practice, while periprosthetic joint infection (PJI) is its catastrophic complication. Biofilms are special membrane-like structures that bacteria form on the surface of biomedical materials that protect them from antibiotics and the immune system, making eradication difficult. The drug resistance of pathogenic bacteria caused by PJI is one of the reasons for postoperative PJI persistence, and it is also the focus of PJI treatment. At present, the overall therapeutic effect of PJI remains not ideal with a high failure rate, which is related to the lack of a safe, effective and easy implement method to remove the bacterial biofilm. Therefore, this paper will review the removal strategies of biofilm from physical removal, chemical removal and biological removal, in order to provide a reference for the clinical treatment of PJI.