Abstract:[Objective] To analyze the highly cited papers in the Orthopedic Journal of China, so as to provide references for topic se-lection and submission, and further enhance the academic quality and influence of the journal. [Methods] The citation numbers of all pa-pers published in this journal from January 2016 to December 2021 were retrieved and counted based on the China National Knowledge In-frastructure (CNKI) China Citation Database, in order to determine the highly cited papers, and literature type distribution, topic distribu-tion, and keyword analysis. [Results] From January 2016 to December 2021, a total of 3 363 articles were published, including 3 135 validpapers. Of them, 2 973 theses were cited, with the top 5% of cited papers of 152. These highly cited papers had a total citation frequency of6 708 times, with an average citation frequency of 44.1 times per paper, while the papers cited ≥50 times were 41 articles. Among the 41theses, 24 were from affiliated hospitals of universities, accounting for 58.5%. In terms of topic distribution, the first one was 12 articles re-lated to spine, the second was 11 articles related to joints, and the third was 10 articles related to trauma (including ankle), and the fourthwas 9 papers on other topics. In term of type distribution of the 41 theses, 21 were clinical original articles, 9 reviews, 4 clinical studies,and 2 experience exchanges, as well as 1 expert consensus, 1 diagnosis and treatment norms, 1 meta-analysis, 1 basic research, and 1 nurs-ing conference report respectively. The most frequently used keywords were "knee " (8 times), "percutaneous transforaminal endoscope" (7times), and "osteoarthritis" (6 times). [Conclusion] The highly cited articles in this journal focuses are characterized on spine in topics, clin-ical original article in published type. The main content of Orthopaedic Journal of China is cutting-edge orthopedic hot field, and unique re-search.