骨关节炎发病相关细胞因子的研究现状△

Research status of cytokines related to osteoarthritis pathogenesis

摘要:

骨关节炎是老年人群中最常见的慢性退行性疾病。近些年，骨关节炎的全球发病率日益增加，但因对骨关节炎的机制及其发展规律缺乏全面了解，目前仍无法彻底治愈骨关节炎，所以本文详细介绍了与骨关节炎发病机制有关的致病因子，如细胞因子、基质金属蛋白酶、炎症介质酶以及其他一些致病因子，并对其在骨关节炎中的作用和机制进行综述。

Abstract:

Osteoarthritis is the most common chronic degenerative disease in the elderly population. In recent years, the global inci-dence of osteoarthritis has been increasing, but there is still no complete cure for osteoarthritis, partly because of the lack of a comprehensiveunderstanding of the mechanism of osteoarthritis and its development. Therefore, this article introduced in detail the pathogenic factors relat-ed to the pathogenesis of osteoarthritis, such as cytokines, matrix metalloproteinases, inflammatory mediators and other pathogenic factors,and reviewed their roles and mechanisms in osteoarthritis.