Abstract:[Objective] To investigate the clinical efficacy of anteromedial approach combined with lateral approach in surgical treatment of terrible triad of the elbow (TTE). [Methods] A retrospective study was done on 15 patients who had TTE treated surgically through anteromedial approach combined with lateral approach in our hopsital from October 2017 to October 2022. Clinical and imaging data were evaluated. [Results] All the 15 patients underwent operation smoothly, with average operation time of (218.6±70.5) min, and average intraoperative blood loss of (150.0±116.5) ml, and followed up for (15.1±4.1) months in an average. As time went preoperatively, 3 months after surgery and the last follow-up, the VAS score significantly reduced [(8.1±0.9), (1.3±0.6), (0), P<0.001] , while the varus stress test [-/1+/2+/ 3+, (0/7/7/1), (12/3/0/0), (15/0/0/0), P<0.001], and valgus stress test [-/1+/2+/3+, (0/1/12/2), (13/2/0/0), (15/0/0/0), P<0.001] significantly improved. Compared with that 3 months after surgery, Mayo score [(77.7±8.2), (94.3±5.9), P<0.001] was significantly increased at the last follow-up, whereas the elbow flexion-extension ROM and forearm rotation ROM remained unchanged (P>0.05). Radiographically, the humeroulnar congruence [concentric/eccentric/dislocation, (1/9/5), (12/3/0), (15/0/0), P<0.001] significantly improved 3 months after surgery and at the last follow-up compared with that preoperatively. [Conclusion] This combination, treating ulnar coronoid fractures through anteromedial approach passing between teres pronator and the flexor carpi radialis, and treating the radial head fracture through lateral approach, is safe and effective treatment for TTE.