Abstract:[Objective] To compare the clinical efficacy of retrograde tibial intramedullary nail (RTIN) versus minimally invasive percutaneous plate osteosynthesis (MIPPO) in the treatment of extraarticular fractures of the distal tibia. [Methods] A retrospective research was done on 40 patients who received surgical treatment for distal tibial extraarticular fractures in our hospital from June 2021 to December 2022. According to the preoperative doctor-patient communication, 18 patients received RTIN, while the remaining 22 patients were treated with MIPPO. The perioperative, follow-up and imaging data of the two groups were compared. [Results] All patients were operated on successfully. The RTIN cohort was significantly less than the MIPP cohort in terms of total incision length [(6.7±0.5) cm vs (10.4±1.1) cm, P<0.001] and hospital stay [(13.9±1.9) days vs (15.6±2.0) days, P=0.012], whereas the former consumed significantly more intraoperative fluoroscopy times than the latter [(14.0±2.7) times vs (11.6±2.6) times, P=0.006]. All patients in both cohorts were followed up from 12 months to 20 months, and the RTIN group regained full weight-bearing activity significantly earlier than the MIPPO group [(85.9±11.3) days vs (98.6±23.5) days, P=0.042]. The VAS and AOFAS scores, as well as ankle flexion-extension ROM in both groups were significantly improved over time (P<0.05), whereas which were not statistically significant between the two groups at any time points accordingly (P> 0.05). The RTIN cohort proved significantly superior to the MIPPO in terms of soft tissue irritation [no/yes, (18/0) vs (15/7), P=0.008], while, the squat capacity and Johner-Wruh scale were not significantly different between the two groups at the last follow-up (P>0.05). With respect of imaging, the bilateral tibial length discrepancy, lateral distal tibial angle (LDTA) and anterior distal tibial angle (ADTA) were significantly improved in both groups at the latest follow-up compared with those preoperatively (P<0.05), while which were not significantly different between the two groups at time point accordingly (P>0.05). All patients in both cohorts had bone healed well at the latest follow-up. [Conclusion] Both percutaneous internal fixation techniques do effectively treat distal tibial extraarticular fractures, in comparison, the retrograde intramedullary nailing achieves better clinical consequence over the minimal invasive percutaneous plate osteosynthesis.