Abstract:[Objective] To evaluate the clinical efficacy of open reduction and internal fixation (ORIF) with mini locked titanium platefor Lisfranc injury complicated with cuboid compression fractures. [Methods] A retrospective study was performed on 21 patients who re-ceived ORIF for Lisfranc injury complicated with cuboid compression fractures in our hospital from October 2015 to January 2018, includ-ing 13 males and 8 females. The clinical and imaging data were evaluated. [Results] All patients had ORIF conducted successfully withoutvascular and nerve injury, and followed up for a mean of (29.3±8.9) months. During the follow-up, 1 patient of them underwent revision tar-sometatarsal fusion due to significant pain in the middle foot during walking. Compared with those preoperatively, the VAS scores [(5.3±0.6), (1.2±0.9), P<0.001] and AOFAS ankle-hindfoot score [(50.1±3.4), (83.0±6.3), P<0.001] were significantly improved at th last followup.The clinical outcome were marked as excellent in 3 cases, good in 14 cases, fair in 4 cases poor in 0 case by the time of latest followup,with excellent and good rate of 94.4%. As for imaging, the step-off sign (SOS) [(4.7±1.2) mm, (1.3±0.5) mm, P<0.001], M1-M2 distance[(13.4±1.9) mm, (2.3±0.6) mm, P<0.001], C1-C2 distance [(3.1±1.4) mm, (1.7±0.5) mm, P<0.001], and Meary's angle [(18.8±8.9)°, (2.8±0.9)°, P<0.001] were significantly improved at the last follow-up compared with those preoperatively. Up to the last follow-up, 2 patientshad mild lateral column shortening deformity and 11 patients had signs of metatarsal arthritis in varying extent. [Conclusion] ORIF withmini locking titanium plate for Lisfranc injury complicated with cuboid bone compression fractures do effectively restore the length of thelateral column and avoid the occurrence of secondary foot deformities, and achieve satisfactory clinical consequence.