Abstract:[Objective] To investigate the short and medium term outcome of arthroscope-assisted repair of the anterior talofibular liga-ment (ATFL) and deltoid ligament (DL) simultaneously for rotational instability of the ankle. [Methods] A retrospective study was conduct-ed on 18 patients who had ATFL and DL repaired simultaneously under arthroscope in our hospital from January 2018 to December 2021,with complete follow-up data. The clinical and imaging data were evaluated at the time points preoperatively and at the latest follow-up.[Results] All the 18 patients had operation performed successfully with the operation time of (56.7±7.2) min, intraoperative blood loss of(9.4±1.4) mL, ambulation time of (14.9±0.5) days. All patients got incisions healed well without major neurovascular injury, deep incisioninfection, or other serious complications, and followed up for a mean of (16.4±2.1) months. Compared with those preoperatively, the AOFASscore [(65.1±8.3), (93.7±4.4), P<0.001] and ankle dorsal extension-plantar flexion ROM [(61.3±3.7)°, (68.0±2.3)°, P<0.001] increasedsignificantly; while pain VAS score [(3.8±1.0), (0.7±0.7), P<0.001] and ankle inversion-eversion ROM [(47.2±2.2)°, (44.2±1.7)°, P<0.001] significantly decreased at the latest follow-up. In addition, the ankle anterior drawer test, valgus test, and varus test significantly im-proved at the last follow-up compared with the preoperative test (P<0.001). As for imaging, there were no significant changes in talocruralangle (TCA) and medial clear space (MCS) at the last follow-up (P>0.05). All patients had no significant degenerative changes in the anklejoint. [Conclusion] The simultaneous arthroscopic ATFL and DL repair do effectively improve the rotational instability of the ankle.