Abstract:[Objective] To investigate the clinical outcome of tarsometatarsal fusion in the treatment of hidden Lisfranc injury. [Methods] A retrospective study was conducted on 19 patients who had hidden Lisfranc injury treated by tarsometatarsal fusion in our hospitalfrom April 2010 to May 2020 . The clinical and imaging data were analyzed. [Results] All the patients had operation performed successful-ly without neurovascular injury and other complications, and followed up from 12 months to 24 months. The VAS score significantly re-duced [(5.2±1.6), (1.5±0.8), (1.1±0.7), P<0.001], while the AOFAS score [(48.5±5.2), (75.8±8.7), (80.8±6.7), P<0.001], SF-36 score [(40.1±5.9), (70.7±4.0), (75.4±6.3), P<0.001] increased significantly over time. In terms of image, the clearance between the cuniform 1 and meta-tarsal 2 (C1-M2) in X ray of non weight bearing position [(3.6±1.4), (1.2±0.2), (1.0±0.3), P<0.001] and the clearance of M1-M2 [(4.6±1.1),(1.6±0.3), (1.4±0.4), P<0.001] significantly reduced with time. [Conclusion] Tarsometatarsal fusion is a safe and effective operation for hid-den Lisfranc injury,