Abstract:[Objective] To investigate the clinical outcome of single plane valgus retrograde intramedullary nail used in tibiotalocalca-neal arthrodesis (TTCA) for end-stage ankle arthrosis with hind foot deformity. [Methods] A retrospective study was conducted on 26 pa-tients who underwent TTCA with single plane valgus retrograde intramedullary nail for terminal ankle arthrosis in our hospital from January2017 to November 2022. The clinical and imaging documents were evaluated. [Results] All the patients were operated on successfully with-out neurovascular injury and other complications, and followed up for an average of (38.5±21.9) months. With time preoperatively, 3 monthspostoperatively and at the latest follow-up, the VAS score was significantly decreased [(6.1±1.5), (3.7±0.7), (1.6±0.6), P<0.001], while AO-FAS score [(45.3±4.9), (73.9±6.5), (77.8±5.9), P<0.001] increased significantly. As for imaging, the varus coronal tibiocalcaneal angle (CT-CA) [(14.2±7.8)°, (4.4±1.1)°, (4.7±0.7)°, P=0.014], and the valgus CTCA [(10.4±1.1)°, (3.9±0.5)°, (4.5±0.5)°, P=0.002] significantly re-duced, while the sagittal tibiocalcaneal angle (STCA) had no significant changes (P>0.05). Up to the last follow-up, 25 patients had good fu-sion, with an average fusion time of (3.8±0.9) months, and the fusion rate of 96.2%. [Conclusion] For end-stage ankle arthrosis with hindfoot deformity, single plane valgus retrograde intramedullary nail used in TTCA achieves satisfactory clinical consequence with less risk ofintraoperative neurovascular injury.