Abstract:[Objective] To investigate the efficacy of ultrasound-CT fusion imaging for percutaneous transforaminal endoscopic discec-tomy (PTED). [Methods] A total of 54 patients who were undergoing PTED for disc herniation were enrolled into this study in our hospitalfrom January 2021 to January 2023, and randomly divided into two groups, with 27 patients in each group. The fluoroscopy group had PTEDperformed under C-arm X-ray machine guide, while the image fusion group had PTED conducted with guide of ultrasound-CT fusion image.Perioperative, follow-up and imaging data were compared between the two groups. [Results] The image fusion group proved significantly su-perior to the fluoroscopy in terms of the operation time [(89.2±10.7) min vs (109.3±11.8) min, P<0.001], puncture time [(9.2±1.1) min vs(13.8±2.5) min, P<0.001], intraoperative fluoroscopy times [(3.8±0.8) times vs (6.2±0.9) times, P<0.001], and success rate of first puncture[cases (%), 22 (81.5) vs 15 (55.6), P=0.040]. All patients in both groups were followed up for 12 months, and the low back pain and leg painVAS scores, as well as ODI and JOA scores in both groups were significantly improved over time (P<0.05). The image fusion group was signif-icantly better than the fluoroscopy group regarding low back pain VAS score [(3.6±0.9) vs (4.5±1.1), P<0.001; (0.9±0.2) vs (1.3±0.3), P<0.001], leg pain VAS score [(3.2±0.8) vs (3.7±0.9), P<0.001; (1.1±0.2) vs (1.6±0.5), P<0.001], ODI score [(45.5±5.6) vs (51.8± 6.7), P<0.001;(20.4±2.6) vs (25.4±3.4), P<0.001], JOA score [(16.2±2.3) vs (14.1±2.5), P<0.001; (23.5±3.2) vs (19.7±3.5), P<0.001] 1 month after surgeryand at the latest follow-up. As for imaging, the ratio of vertebral canal occupied area was significantly decreased at the last follow-up com-pared with that preoperatively (P<0.05), while the vertebral space height and lumbar lordosis angle remained unchanged significantly in bothgroups (P>0.05). At corresponding time points, there were no statistically significant differences in the above imaging indicators (P>0.05).[Conclusion] Ultrasonic CT fusion imaging PTED does significantly improve the pain symptom and lumbar function, and enhance the safetyof surgery.