铁死亡在骨关节炎发展中的作用△

The role of ferroptosis in pathogenesis of osteoarthritis

摘要:

骨关节炎是一种涉及关节组织病理变化的常见退行性疾病，发病机制十分复杂，涉及机械负荷、损伤、代谢及炎症刺激等方面，严重影响患者的生活质量。铁死亡作为一种新发现的以脂质过氧化物累积为特征的铁依赖性的细胞死亡方式，主要涉及铁代谢与氧化还原平衡等机制，参与了多种退行性疾病的发生发展过程。同时，关于铁死亡与骨关节炎之间的研究也越来越多，为深入探索其作用机制提供了大量的证据。因此，本文综述了铁死亡在关节炎中的发病机制及治疗的研究进展，旨在为临床治疗骨关节炎提供早期预防策略的可能性，同时探讨进一步的研究方向和治疗靶点。

Abstract:

Osteoarthritis is a common degenerative disease involving pathological changes in joint tissues, with a complex pathogenesis involving mechanical loading, injury, metabolism and inflammatory stimuli, which seriously affects the quality of life of the patients. Ferroptosis, a newly discovered irondependent cell death mode characterized by lipid peroxide accumulation, mainly involves iron metabolism and redox homeostasis, and is involved in pathogenesis of many degenerative diseases. Meanwhile, studies on the association between ferroptosis and osteoarthritis have been increasing, providing a large amount of evidence for in-depth exploration of its mechanism of action. Therefore, this review summarizes the research progress on the pathogenesis and treatment of ferroptosis in osteoarthritis, aiming to find the possibility of providing early prevention strategies for the clinical treatment of osteoarthritis, as well as exploring further research directions and therapeutic targets.