破骨-软骨细胞交互调控在骨关节炎作用的研究现状△

Research status of osteoclast-chondrocyte crosstalk in osteoarthritis

摘要:

骨关节炎 （osteoarthritis, OA） 是骨科常见的关节退行性疾病，导致关节内软骨和软骨下骨、滑膜等组织发生病变， 产生疼痛、活动受限等症状，影响生活质量。目前临床对于 OA 的治疗除终末期的关节置换外，尚没有较好的治疗手段，这也导致 OA 给医疗系统和社会经济带来巨大的负担。破骨细胞是具有骨吸收作用的大型多核细胞，在 OA 中参与软骨下骨重塑并诱导骨赘和骨囊肿的形成。软骨细胞作为关节软骨内唯一存在的细胞，发挥着软骨形成和维持软骨功能的作用，在 OA 中参与软骨降解。鉴于目前关于破骨-软骨细胞交互调控在 OA 中的作用报道较少，本文查阅了相关文献并对破骨-软骨细胞交互调控综述如下。

Abstract:

Osteoarthritis (OA) is a common joint degenerative disease, leading pathology of intro-articular cartilage, subchondral bone, synovial membrane and other tissues, which significantly affect patients' quality of life. Currently, there is no effective treatment for osteoarthritis other than joint replacement for the end-stage patients, which also results in a significant burden on the medical system and social economy. Osteoclast, a large multi-nucleated cell, plays a clear role in bone resorption. It participates in subchondral bone remodeling and induce the formation of osteophyte and bone cysts in OA. Chondrocyte, cell in articular cartilage, plays a crucial role in both cartilage formation and maintenance, as well as participating in chondrolysis in OA. At present, there are limited reports on the role of osteoclasts-chondrocytes crosstalk in osteoarthritis degenerative diseases. This article reviewed the relevant literature and summarized the osteoclasts-chondrocytes crosstalk