HIF-1α信号通路在股骨头坏死作用的研究现状△

Current research on role of HIF-1α signal pathway in osteonecrosis of femoral head

摘要:

股骨头坏死（osteonecrosis of the femoral head, ONFH）是骨科常见的髋部疾病之一，目前还没有明确的药物可以完全阻止 ONFH 的进展。近年来，HIF-1α 信号通路在 ONFH 中的研究逐渐增多，研究发现，HIF-1α 信号通路在间充质干细胞、 内皮祖细胞和软骨细胞中被激活，进而刺激细胞分泌血管生成和骨修复相关细胞因子，从而促进 ONFH 的修复。此外许多药物也能够通过激活细胞内 HIF-1α 信号通路促进 ONFH 的骨修复和血管生成，在治疗 ONFH 方面具有潜在的应用价值。本文通过综述 HIF-1α 信号通路在 ONFH 作用的研究现状，为临床上治疗 ONFH 提供更多的方法和思路。

Abstract:

Osteonecrosis of the femoral head (ONFH) is one of the common hip diseases in orthopaedics, and there is no definite drug that can completely prevent the development of ONFH. In recent years, the study on the role of HIF-1 α signaling pathway in ONFH has gradually increased. It has been found that HIF-1α signaling pathway is activated in mesenchymal stem cells, endothelial progenitor cells and chondrocytes, this in turn stimulates the secretion of angiogenesis and bone repair-related cytokines to promote ONFH repair. In addition, many drugs can also promote bone repair and angiogenesis of ONFH by activating intracellular HIF-1α signaling pathway, which has potential application value in the treatment of ONFH. In this article, we reviewed the research status of HIF-1α signal pathway in ONFH, and provided some potential approach and ideas for clinical treatment of ONFH.