Abstract: [Objective] To evaluate the clinical efficacy of 3D printing-assisted bridging combination fixation of Vancouver type B1 and C periprosthetic fractures of the femur. [Methods] A retrospective study was conducted on 27 patients who had Vancouver type B1 and type C periprosthetic fractures fixed by 3D printing assisted bridging combination fixation from March 2016 to May 2022. The clinical and imaging documents were evaluated. [Results] Of the 27 patients, there were 15 cases of Vancouver type B1 fractures and 12 cases of Vancouver type C fractures. There were no significant differences in operation time [(107.3±18.7) min vs (119.2±19.3) min, P=0.713] and intraoperative bleeding [(385.3±114.1) mL vs (420.8±160.2) mL, P=0.381] between the two groups. No complications such as wound infection, loose internal fixation, fracture nonunion or malunion occurred in anyone of them during follow-up. There were no significant differences in fracture healing time [(3.8±1.3) months vs (4.2±1.6) months, P=0.258], Harris score before injury [(86.3±3.5) vs (86.9±3.3), P= 0.903] and Harris score 12 months after revision [(84.3±3.4) vs (85.2±3.1), P=0.785] between the two types of the fractures. [Conclusion] 3D printing-assisted bridging combination fixation of Vancouver type B1 and C periprosthetic fractures of the femur after THA achieves satisfactory short-medium term clinical consequence, and there is no significant difference in the treatment outcome between the two fracture types.