Abstract: [Objective] To introduce the technique and clinical consequence of fracture matching recognition technique in repairing severe foot and ankle wound. [Methods] From March 2015 to August 2020, 27 patients with severe foot and ankle wound were treated with the "fracture-matching recognition technique" to effectively identify the tissue in situ. On basis of thorough debridement, the multi-tissue integration reconstruction procedures combined with new method searching vascular vessels and innovative tissue survival promoting ways were adopted for repair. [Results] All the patients had surgical procedures performed smoothly without serious complications such as limb necrosis. Except early flap swelling occurred in 4 cases, which basically subsided 7 days later, and delayed wound healing happened in another patient, who got healed gradually after dressing change, all patients had the recipient and donor areas of the skin flap healed well. The followup period lasted for (23.8±7.5) months in a mean. With time elapsed before discharge, 3 months after surgery and at the last follow-up, the VAS score [(4.0±1.3), (2.30±1.1), (1.6±0.8), P＜0.001], AOFAS score [(54.3±3.2), (71.0±3.0), (83.9±3.3), P＜0.001], dorsal-plantar flexion range of motion (ROM) [(42.7±2.9)°, (52.6±2.6)°, (64.2±3.2)°, P＜0.001], inversion-eversion ROM [(34.7±3.6)°, (40.7±3.6)°, (53.6±3.9)°, P＜ 0.001]，Highet grade distal to the wound [S0/S1/S2/S3/＞S3, (2/9/11/3/2), (1/6/9/7/4), (0/2/3/6/16), P＜0.001]，static 2-point discrimination (2PD) [(38.0±4.7) mm, (32.3±2.2) mm, (19.0±0.6) mm, P＜0.001]，and moving 2-point discrimination (m2PD) [(10.1±0.6) mm, (8.4±0.9) mm, (5.5±0.3) mm, P＜0.001] were significantly improved. [Conclusion] The applying "fracture matching recognition technique" combined with microsurgical technique to repair severe foot and ankle wound does save the limb function to the maximum extent and reduce the disability rate.