Abstract:[Objective] To compare the clinical efficacy of robot-assisted total knee arthroplasty (TKA) versus traditional technique TKA for knee osteoarthritis complicated with varus deformity. [Methods] A retrospective study was conducted on 92 patients who received TKA for knee osteoarthritis complicated with varus deformity in our hospital from January 2021 to October 2023. According to preoperative doctor-patient communication, 46 patients received robot-assisted TKA (robot group), while other 46 patients received traditional TKA (traditional group). The perioperative, follow-up and imaging data were compared between the two groups. [Results] Although the robot group consumed significantly longer operative time than the traditional group [(97.2±7.8) min vs (86.7±6.5) min, P<0.001], the former had significantly less blood loss than the latter group [(224.1±21.8) mL vs [240.2±23.6] mL, P<0.001]. However, there was no significant difference in incision length, bed rest time, hospital stay, incision healing time and complication rate between the two groups (P>0.05). The WOMAC score and VAS score were significantly decreased, while HSS score and extension-flexion ROM were significantly increased in both groups over time (P<0.05), which were not statistically significant between the two groups at any time points accordingly (P>0.05). Regarding to imaging, the FTA was significantly decreased, while the MPTA and PTS were increased in both groups postoperatively compared with those preoperatively (P<0.05). At the latest follow-up, the robot group had significantly lesser FTA [(172.7±10.5)° vs (178.4±12.6)°, P<0.05], while significantly greater MPTA than the traditional group [(87.7±7.4)° vs (78.8±6.5)°, P<0.001]. [Conclusion] Robot-assisted TKA for knee osteoarthritis complicated with varus deformity achieves the same clinical efficacy as traditional TKA surgery. However, the robot-assisted surgery has longer operation time, less blood loss, and better lower limb alignment correction.