细胞自噬信号通路在骨关节炎发病的作用△（开放获取）

Role of autophagy signaling pathway in the pathogenesis of osteoarthritis

摘要:

骨关节炎是老年常见的一种复杂的多因素退行性关节疾病，包括且不局限于机械外力、老化等因素，最终导致关节软骨退化损伤，是软骨细胞外基质降解和软骨细胞减少为特征的关节疾病。自噬是一种通过溶酶体降解来维持细胞内稳态的机制， 在一定程度上有减缓骨关节炎进展的作用。体内多种信号传导通路可以影响自噬对骨关节炎的作用，为了探索不同信号通路对自噬的影响，本团队查阅大量文献，希望可以发现新的治疗思路。

Abstract:

Osteoarthritis is a common complex and multifactorial degenerative joint disease among the elderly, which is caused by various factors including but not limited to mechanical stress and aging, and is characterized by the degradation of extracellular matrix of chon-drocytes and the reduction of chondrocytes. Autophagy is a mechanism that maintains intracellular homeostasis through lysosomal degradation, and it plays a role in slowing down the progression of osteoarthritis to some extent. Various signaling pathways in the body can affect the role of autophagy in osteoarthritis. In order to explore the effects of different signaling pathways on autophagy, this study aims to discover new therapeutic strategies by reviewing a large number of literature.