针刀疏筋解结术对Ca2+/NFATc1信号通路骨代谢影响△

Research progress of the effect of acupotomy on bone metabolisms based on Ca2+ / NFATc1 signaling pathway in osteoarthritis

摘要:

膝关节骨性关节炎（knee osteoarthritis, KOA）是一种骨科常见的退行性全关节疾病，以关节疼痛、肿胀、僵硬和活动受限等为临床表现，严重影响我国 30%老年人群生活质量。关于 KOA 发病机制和最佳治疗方案目前尚未完全明确。随着中西医结合方案在骨关节疾病治疗方面的应用，针刀疏筋解结术被证实能有效缓解 KOA 患者关节疼痛，改善关节部位骨代谢， 改善关节功能。同时，近年来 Ca2+ /NFATc1 信号通路在 KOA 发生、发展过程中的作用逐渐被认知，其在关节软骨调控方面起着重要作用。这将为 KOA 发病机制深入研究和最佳治疗方案的探究提供新的思路。本研究针对针刀疏筋解结术对 Ca2+ /NFATc1 信号通路骨代谢影响的研究进展进行综述，以期推动针刀疏筋解结术在 KOA 患者中的推广应用。

Abstract:

Knee osteoarthritis (KOA) is a common degenerative total joint disease in orthopaedics with clinical manifestations including joint pain, swelling, stiffness and limited mobility, which seriously affect the quality of life of 30% of the elderly population in China. The pathogenesis and optimal treatment of KOA are not fully understood. With the application of integrated Chinese and Western medicine in the treatment of bone and joint diseases, acupotomy therapy has been proved to be effective in alleviating joint pain in KOA, improving bone metabolism around the joint and improving joint function. Meanwhile, in recent years, the role of Ca2/NFATc1 signaling pathway in the occurrence and development of KOA has been gradually recognized, and it plays an important role in the regulation of articular cartilage. This will provide new ideas for the in-depth study of the pathogenesis of KOA and the exploration of the best treatment plan. In this study, we reviewed the research progress of the effect of acupotomy on bone metabolism in Ca2/NFATc1 signaling pathway, in order to promote the application of acupotomy in KOA.