Abstract:[Objective] To evaluate the pitfalls and postoperative complications in one-stage repair and reconstruction for multiple ligament injuries of the knee, and to analyze the countermeasures. [Methods] A retrospective study was conducted on 50 patients who had knee multiple ligament injuries treated surgically in our hospital from 2011 to 2024. The incidence of intraoperative traps and postoperative complications and their treatment were hierarchically analyzed. [Results] A total of 18 patients were included into this study after the patients who lose the follow-up were excluded. The patients were compared in stratifications based on time interval between injury and surgery, number of ligaments involved, whether the knee was dislocated at hospital admission, and artificial or autogenous grafts used. There were no significantly differences in terms of Lysholm, IKDC and VAS scores between the early operation group and delayed operation group, two ligaments involved group and three ligaments involved group, dislocation group and non-dislocation group, artificial ligament graft group and tendon autograft group (P>0.05). Complications occurred in 6 of 18 cases (33.3%), including 5 cases of knee stiffness after operation, which resolved without adverse consequences after manual release in 1 case, and rehabilitation exercise in 4 cases. In term of stratified comparison, the artificial ligament group had significantly ankylosis ratio and the tendon autograft group (66.7% vs 8.3% , P= 0.022), whereas the two ligament involved group had significantly less ankylosis ratio than the three ligaments involved group (0 vs 35.7%, P<0.001). [Conclusion] Ankylosis is the most common complication after one-stage repair and reconstruction for the multiple ligament injuries of the knee, which is more likely to occur after one-stage reconstruction with artificial ligament graft, or for three ligaments involved. There was no significant difference in clinical outcomes between early and delayed surgery and with or without dislocation at hospital admission