Abstract:[Objective] To compare the clinical outcome of arthroscopic anterior cruciate ligament (ACL) reconstruction with two kinds of femoral side suspension fixation. [Methods] A retrospective research was done on 106 patients who received unilateral arthroscopic single-bundle ACL reconstruction with hamstring tendon autograft from June 2021 to June 2023. According to doctor-patient communication preoperatively, 46 patients had ACL reconstructed by using EndoButton fixed loop for femur side fixation, while other 60 patients were by using Rigidloop adjustable loop for femoral side fixation. The perioperative period, follow-up and imaging documents were compared between the two groups. [Results] There were no statistically significant differences in operation time, intraoperative blood loss, first time to ambulation, hospital stay, incision healing quality, incision healing time, and incidence of complications between the two groups (P>0.05). All patients in both groups were followed up for more than 12 months, and there was no a significant difference in the time for recovery exercise between the two groups (P>0.05). The IKDC score, Lysholm score and KT-1000 side to side difference were significantly improved over time in both groups (P<0.05), whereas which proved not statistically significant between the two groups at any corresponding time points (P>0.05). In terms of image, the anterior tibial displacement under anterior drawer stress was significantly declined with time in both groups (P<0.05), which was no statistical significance between the two groups at any time points accordingly (P>0.05). However, the EndoButton group had significantly greater inner diameter of the tibial tunnel than the Rigidloop group at 12 months after operation [(8.4±0.8) mm vs (7.9±0.6) mm, P<0.05]. [Conclusion] Both the fixed loop and the adjustable loop fixation of the tendon graft femoral side in arthroscopic ACL reconstruction do achieve good and consistent short-term consequence, but the EndoButtonthe fixed loop for femoral side fixation has more obvious tibial tunnel enlargement than the Rigidloop adjustable loop.