Abstract:[Objective] To introduce the surgical technique and preliminary clinical results of surgical treatment for the irreducible knee dislocation (IKD). [Methods] From January 2015 to December 2023, 3 patients received first stage open reduction and second stage arthroscopic cruciate ligament reconstruction for IKD. In the first stage of surgery, manual reduction was initially attempted. If manual reduction failed, the medial side of the knee was incised to expose the medial collateral ligament, medial retinaculum, and Stieda fracture. After releasing the locked medial structures, the knee was reduced properly. As two anchors were placed on the medial femoral condyle, and the medial collateral ligament, medial retinaculum, and Stieda fracture were fixed to the medial femoral condyle. The ipsilateral semitendinosus tendon autograft could be used to reconstruct or augment the medial structures if necessary. After rehabilitation during the interval between the two-stage operations, arthroscopic ACL and PCL reconstructions were conducted in the second stage. The bone tunnels for PCL were created first, followed by those for ACL. Finally, the ACL was reconstructed by using contralateral hamstring tendons, while the PCL was reconstructed by an artificial ligament graft (LARS). [Results] All three patients had two-stage operations performed successfully without severe complications. Follow-up periods ranged from 12 to 20 months, with an average of (15.5 ± 3.3) months. Lysholm score increased from (47.0±1.3) preoperatively to (86.3±1.8) at the last follow-up (P<0.05), IKDC2000 score increased from (48.1±1.8) to (85.0±1.2) (P< 0.05), KSS score from (45.0±1.5) to (88.0±1.1) (P<0.05), and medial joint space width from (12.3±2.2) mm to (1.7±0.8) mm accordingly (P< 0.05). At the last follow-up, all 3 patients had mild anterior-posterior instability with axial shift test (-), anterio drawer test (-) and posterio drawer test (+). MRI confirmed the proper location of the bone tunnels. [Conclusion] The staged surgical treatment for IKD demonstrates satisfactory outcomes in terms of knee stability and functional recovery.