Abstract: [Objective] To evaluate the clinical consequence of a single Kocher-Langenbeck (K-L) approach for open reduction and internal fixation (ORIF) of acetabular transverse fracture with or without posterior wall fracture. [Methods] A retrospective study was conducted on 23 patients who received ORIF through a single K-L approach for acetabular transverse fracture with or without posterior wall fracture in the Department of Traumatic Orthopaedics of our hospital from 2018 to 2023, including 15 males and 8 females, aged 22-71 years with an average age of (35.6±9.6) years. The clinical and imaging data were evaluated. [Results] All the patients were operated on successfully with no serious complications such as death and massive hemorrhage, whereas with operative time of (184.7±21.1) min, intraoperative blood loss of (413.9±87.9) mL, and intraoperative fluoroscopy times of (26.6±4.1) times. One patient experienced foot numbness and weakened dorsal extensor strength after surgery, received neurotrophic drugs to treat the symptoms, and got the symptoms significantly relieved 3 months after surgery. None of the patients had wound infection, symptomatic thrombosis and other complications. All patients were followed up for 6-63 months, with an average of (31±9.4) months. The time to return to full weight-bearing activity ranged from 1.2 months to 2.6 months after operation, with an average of (1.7±0.3) months. At the last followup, of the 23 patients, 19 patients recovered pre-injury sports capacity, whereas 4 patients did not regained pre-injury level. One patient had ectopic ossification, which had a partial effect on hip function. As for imaging, according to the Mata criteria, the fracture reduction quality of 23 patients was rated as excellent in 7 cases, good in 12 cases, and poor in 4 cases. At the last follow-up, X-ray showed fracture healed in all patients, with healing time ranged from 8 weeks to 14 weeks. No implant loosening or fracture was found in anyone of them. [Conclusion] For transverse acetabular fracture with or without posterior wall fracture, a single K-L approach does meet the need of ORIF to obtain satisfactory clinical consequence.