Abstract:Development of 3D printing technology provides the basis for the innovation and clinical application of personalized artificial vertebrae. 3D printed artificial vertebral body can be accurately reconstructed and achieve immediate stability. With pore structure of the distal and proximal contact surfaces of the artificial vertebral body like trabecular bone, the endplate of the vertebral body might achieve bone ingrowth and finally obtain permanent stability. Based on the advanced retrieval function of Web of science, 7 782 literatures on 3D printed orthopedic medical devices published from 1990 to 2023 were retrieved, with explosive growth beginning in 2012 and the largest growth from 2019 to 2020. In term of literature visualization analysis, China (30.7%) was far ahead and ranked first in the world, while the United States (20.7%) ranked second. The total number of articles published by China and the United States accounts for more than half of the world's total. Medical interaction is the most prominent feature of personalized 3D printed medical devices different from traditional medical devices, and the doctor team should master the relevant principles and processes of 3D printing, propose the requirements of implant design, and implement the necessary verification of functional suitability and anatomical matching. Personalized artificial vertebra can be customized and patient-matched. The artificial vertebra is divided into two parts: the main body of the vertebra and the auxiliary device. The auxiliary fixation devices are added according to the actual needs of the implant design. Functional 3D printed medical devices loaded with growth factors, anti-tumor drugs, anti-tuberculosis drugs through surface modification is one of the future development directions.