Abstract:[Objective] To compare the clinical efficacy of low-profile loop plate (LP) versus hook plate (HP) for fixation of acromiocla- vicular dislocation. [Methods] A retrospective study was conducted on 46 patients who had Rockwood III-V acromioclavicular dislocation treated surgically in our hospitals from January 2020 to June 2023. According to the preoperative doctor-patient communication, 22 patients underwent LP, while other 24 patients underwent HP. The perioperative period, follow-up and imaging data of the two groups were compared. [Results] All patients in both groups had corresponding surgical procedures performed successfully without significant differences in operation time, hospital stay, healing grade between the two groups (P>0.05). However, the LP group was significantly superior to the HP group in terms of incision length [(4.1±0.8) cm vs (6.0±0.6) cm, P<0.001], blood loss, [(34.8±5.2) mL vs (55.4±7.8) mL, P<0.001] and active activity time [(1.5±0.1) days vs (1.6±0.0) days, P<0.001]. All patients in both groups were followed up for more than 12 months, and the LP group resumed full weight-bearing activity significantly earlier than the HP group [(46.1±3.0) days vs (53.9±4.7) days, P<0.001]. As time went on, VAS score, Constant-Murley score, forward flexion elevation ROM and abduction elevation ROM were significantly improved in both groups (P<0.05). At 3 months and the last follow-up, the LP group was significantly better than the HP group in terms of VAS score [(2.2±0.8) vs (2.9±0.8), P=0.007; (0.8±0.6) vs (1.9±0.8), P<0.001], Constant-Murley score [(84.2±3.6) vs (79.0±2.7), P<0.001; (93.9±2.0) vs (91.1±2.6), P=0.023], forward flexion elevation ROM [(142.1±6.5)° vs (113.3±11.1)°, P<0.001; (170.2±5.9)° vs (151.7±9.6)°, P<0.001], and abduction elevation ROM [(127.9±5.0)° vs (107.3±8.7)°, P<0.001; (155.9±5.7)° vs (141.0±8.2)°, P<0.001]. As for imaging, the acromiocla-vicular distance (ACD) and coracoclavicular distance (CCD) in both groups decreased significantly after surgery compared with those preoperatively (P<0.05). At any corresponding time points, there were no significant differences in CCD and ACD between the two groups (P> 0.05). [Conclusion] The low-profile loop plate is superior to the hook plate for fixation of acromioclavicular dislocation.