Abstract:[Objective] To explore the clinical efficacy of full-visual spinal endoscopy decompression in the treatment of lumbar spinal lateral recess stenosis (LLRS). [Methods] A retrospective study was conducted on 93 patients who had single-segment LLRS treated by full-visual spinal endoscopy decompression in our hospital from June 2021 to June 2023. The clinical and imaging data were evaluated. [Results] All patients had operation performed successfully without change of surgical approach. However, one patients suffered from dural sac tear during the operation, 2 presented residual low back and leg pain, and 2 patients got aggravated lower extremity numbness after the operation. With time before operation, 3 months postoperatively and at the latest follow-up lasted for (14.9±2.3) months in a mena, the VAS scores of lumbago [(4.7±0.8) score, (1.8±0.4) score, (1.1±0.2) score, P<0.001], VAS of leg pain [(5.8±1.2) score, (1.7±0.5) score, (1.0±0.2) score, P<0.001] and the ODI [(53.1±6.4) score, (22.3±3.8) score, (13.8±2.4) score, P<0.001] significantly decreased, while the spinal canal area [(1.4±0.4) cm2 , (2.1±0.2) cm2 , (2.1±0.2) cm2 , P<0.001], and the anteroposterior diameters of the lateral recess [(2.4±0.3) mm, (4.3±0.4) mm, (4.2±0.4) mm, P<0.001] significantly increased. The excellent and good rate of clinical outcome was of 96.8% at the last follow-up according to the MacNab criteria. [Conclusion] Full-visual spinal endoscopic decompression for LLRS can effectively and relatively safely relieve the nerve root compression in the lateral recess, and alleviate the symptoms of low back and leg pain.