膝骨性关节炎软骨下骨髓水肿样变的研究进展（开放获取）

Research progress of subchondral bone marrow edema-like lesions in knee osteoarthritis

摘要:

膝关节骨性关节炎软骨下骨髓水肿样变是一种常见的 MRI 影像学特征，主要表现为股骨、胫骨和 （或） 髌骨的软骨下骨区域 T2 加权像上的高信号。研究表明，软骨下骨髓水肿样变不仅与膝关节骨性关节炎的疼痛和功能障碍密切相关，而且被认为是疾病进展的潜在驱动因素。近年来，众多研究对软骨下骨髓水肿样变术语的演变、发病机制、组织病理学、流行病学、自然史以及治疗方法进行了深入探讨。本文将对这些文献进行综述，旨在为临床医生和研究人员提供一个关于软骨下骨髓水肿样变在膝关节骨性关节炎中作用的全面概述。

Abstract:

Bone marrow edema-like lesions are a prevalent MRI imaging characteristic in knee osteoarthritis. They are typically observed as areas of increased signal intensity on T2-weighted images within the subchondral bone region of the femur, tibia, and/or patella. Research indicates that subchondral bone marrow lesions changes are not only closely associated with pain and functional impairment in knee osteoarthritis but also are considered a potential driving factor in the progression of the OA. In recent years, a multitude of studies have conducted in-depth explorations into the evolution of the terminology, pathogenesis, histopathology, epidemiology, natural history, and treatment methods related to subchondral bone marrow edema-like changes. This article aims to provide a comprehensive review of these literatures, with the goal of offering clinicians and researchers a thorough overview of the role of subchondral bone marrow edema-like lesions changes in knee osteoarthritis.