Abstract:[Objective] To observe the clinical consequence of minimally invasive cortical osteotomy combined with intramedullary nailing in the treatment of old tibiofibular fractures. [Methods] From October 2021 to February 2023, 13 patients had old tibiofibular fractures over 3 weeks with varying degrees of deformity at the fracture site treated surgically in our department. During the operation, two small incisions were made for cortical osteotomy performed at the fracture site with the surrounding soft tissues released for restoration of the tibial alignment and length. Subsequently, intramedullary nailing was performed through the suprapatellar approach. The clinical and imaging data were evaluated. [Results] All the 13 patients had the operations performed successfully without injury to major blood vessels or nerves. The followup was conducted for more than 12 months, and the clinical fracture healing time was of (7.8±1.5) months in a mean. The VAS [(5.7±1.7) score, (1.6±0.7) score, (1.2±0.4) score, P<0.001], HSS [(54.1±7.0) score, (87.7±2.7) score, (91.5±2.7) score, P<0.001], knee flexion-extension ROM [(92.3±9.3)°, (121.3±25.8)°, (130.6±17.6)°, P<0.001], and ankle AOFAS [(69.5±4.6) score, (88.0±2.9) score, (99.5±0.8) score, P< 0.001] all significantly improved over time preoperatively, 3 months postoperatively and at the latest follow-up. During the follow-up period, no patients had re-fracture or revision surgery. As for imaging, the tibial alignment significantly improved [n, excellent/good/poor, (0/0/13), (4/ 9/0), (10/3/0), P<0.001], while the tibial length discrepancy between both sides significantly decreased over time [(7.3±5.3) mm, (1.3±1.0) mm, (0.4±0.3) mm, P<0.001]. The continuous callus remodeling time was (7.0±1.5) weeks after surgery. By the last followup, all 13 patients achieved complete fracture healing and remodeling, without loosening or breakage of the internal fixation implants. [Conclusion] This small incision osteotomy at the fracture site does effectively assist in the reduction and intramedullary nailing of old tibial fractures with advantages of minimally invasive operation and little impact on the blood supply at the fracture site, and achieves satisfactory clinical outcome.