Abstract:[Objective] To explore the clinical efficacy of cannulated screws combined with mini plates in the treatment of comminuted radial head fractures. [Methods] A retrospective analysis was conducted on the 100 patients who had comminuted radial head fractures treated surgically in our hospital from February 2022 to February 2024. The patients were divided into two groups based on doctor-patient communication, with 50 cases in each group. The combined group was treated with cannulated screws combined with mini-plate, while the simple group was treated only with mini plate. The perioperative, follow-up and imaging documents of the two groups were compared. [Results] All patients in both groups were operated on successfully. The combined group proved significantly superior to the simple group in terms of operation time [(55.3±5.0) min vs (58.2±5.2) min, P=0.040] and intraoperative fluoroscopy times [(5.2±1.1) vs (8.7±1.3), P<0.001]. All patients were followed up for 12 to 16 months. There was no statistically significant difference in the time to regain full weight-bearing activity between the two groups (P>0.05). The VAS, Broderg-Morrey scores, as well as elbow extension-flexion range of motion (ROM) and forarm pronation-supination ROM in both groups were significantly improved over time (P<0.05). The combined group proved significantly better than the simple group in terms of Broderg-Morrey score [(92.4±8.3) vs (87.2±7.8), P=0.021], elbow extension-flexion ROM [(118.6± 6.7)° vs (111.6±6.0)°, P<0.001] and forarm pronation-supination ROM [(142.6±7.9)° vs (135.2±7.2)°, P<0.001] one month after the operation, whereas which became not statistically significant between the two groups at the latest follow-up (P>0.05). As for imaging, the combined group was marked significant better fracture reduction quality than the simple group [excellent/good/poor, (22/24/4) vs (14/23/13), P= 0.037]. However, there was no statistically significant difference in the proportion of fracture healing, the carrying angle, condylar angle and Baumann angle at the corresponding time points between the two groups (P>0.05). [Conclusion] The cannulated screws combined with mini plate does improve the clinical outcome in the treatment of comminuted radial head fractures, shorten the operation time, reduce the number of intraoperative fluoroscopy, enhance the quality of fracture reduction, and promote the recovery of elbow function.