Abstract:[Objective] To compare the clinical outcomes of arthroscopic treatment of Schatzker type Ⅱ~Ⅳ tibial plateau fractures with or without robot assistance. [Methods] A retrospective study was conducted on 53 patients who underwent arthroscopic treatment for Schatzker type Ⅱ~Ⅳ tibial plateau fractures in our hospital from April 2020 to April 2023. Based on preoperative doctor-patient communication, 28 patients were treated with robot-assisted arthroscopic reduction and fixation, while the remaining 25 patients received conventional arthroscopic reduction and fixation without robot assistance. The perioperative, follow-up, and imaging data of the two groups were compared. [Results] All patients successfully completed the surgery. The robot group consumed significantly longer operation time than the conventional group [min, (148.4±58.8) vs (103.6±33.5), P=0.005], but the robot-assisted group proved significantly superior to the conventional group in terms of incision length [cm, (5.4±1.7) vs (8.2±2.7), P<0.001], intraoperative fluoroscopy [times, (5.6±1.4) vs (9.1±1.9), P<0.001], and intraoperative blood loss [mL, (43.4±26.4) vs (70.0±30.6), P=0.001]. In addition, the robot-assisted group resumed ambulation [d, (27.9±1.7) vs (30.4±3.3), P<0.001] and full weight-bearing activity [d, (74.8±11.6) vs (85.5±7.7), P<0.001] significantly earlier than the conventional group. At 6 months postoperatively, the robot-assisted group was significantly better than the conventional group in terms of VAS score [points, (0.4±0.6) vs (1.0±0.9), P=0.011], Rasmussen clinical score [points, (19.2±1.3) vs (18.3±1.1), P=0.017], and knee flexion-extension ROM [°, (114.2±6.2) vs (109.9±6.7), P=0.016], although the differences in VAS and ROM between the two groups became not statistically significant at the last follow-up (P>0.05). As for imaging, the robot group was significantly better than the conventional group regarding fracture healing time on images and K-L grade of joint degeneration at the last follow-up (P<0.05). However, there were no statistically significant differences in Rasmussen radiographic scores between the two groups immediately postoperatively and at the last follow-up (P>0.05).[Conclusion] The robot-assisted arthroscopic reduction and internal fixation take significant advantages of minimally invasive surgery, pain reduction, accelerated fracture healing, and postoperative recovery over the conventional counterpart for Schatzker type Ⅱ~Ⅳ tibial plateau fractures.